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. 2020 Aug 21;11:1988. doi: 10.3389/fmicb.2020.01988

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Copyright © 2020 Liu, Xiang, Zhang, Pang, Su, Liu, Ma and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intracellular activities of AOX, FLD, FDH and formaldehyde concentration at four induction strategies. (A) Activity of alcohol oxidase (AOX, U/g-cell). (B) activity of formaldehyde dehydrogenase (FLD, U/g-cell). (C) activity of formate dehydrogenase (FDH, U/g-cell). (D) formaldehyde concentration (mM). Time zero indicates the initiation of methanol addition. DO-stat strategy (filled green diamond), μ-stat strategy (open blue circle), m-stat strategy (open black triangle), co-stat (filled red square). Asterisk indicates the two-group have significant difference (^∗∗∗P < 0.001).