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. 2020 Feb;2(2):123–136. doi: 10.1016/j.trechm.2019.07.002

Figure 1.

Figure 1

G-Quadruplex (G4) Structures.

(A) Structure of a G-quartet formed by the Hoogsteen hydrogen-bonded guanines and central cation (coloured green) coordinated to oxygen atoms. Crystal structure of human telomeric G4s (Protein Data Bank: 1KF1): (B) top view and (C) side view; backbone is represented by grey tube and the structures are colour-coded by atoms. Schematic representation of unimolecular G4s based on the strand direction: (D) parallel, (E) anti-parallel, and (F) hybrid with a bulge.