Table 2.

Results of cohort 3 of animal experiments

	Animal	Baseline		Round 1				Round 2				Round 3				Round 4
		pH	iCa	pH	iCa	Bolus Ca	Epi	pH	iCa	Bolus Ca	Epi	pH	iCa	Bolus Ca	Epi	pH	iCa	Bolus Ca	Epi
Cohort 3	1	Missing	Missing	Missing	Missing	0	1	Missing	Missing	0	0
	2	7.49	1.08	7.16	1.21	0	1	7.50	0.94	0	0	7.37	0.92	0	0	7.22	1.05	0	0
	3	7.45	1.38	7.47	1.38	0	6	7.04	1.37
	4	7.62	1.25	7.42	1.39	0	0	7.16	1.29	1	0	7.39	1.12	0	1	7.30	1.17	0	1
	5	7.44	1.34	7.01	1.26	1	0	7.28	1.42	1	0	7.40	1.25	1	0	7.21	1.22	0	0
	6	7.47	1.44	7.20	1.25	0	0	7.32	1.29	1	0	7.24	1.49	2	0	Missing	Missing	0	0
	7	7.45	1.38	7.03	0	0	5
	8	7.47	1.40	7.44	1.30	3	0	7.40	1.24	3	0	7.34	1.36	2	0	Missing	Missing	1	2
	9	7.46	1.25	7.47	1.33	1	1	7.28	1.22	5	0	7.40	1.30	5	0	7.30	1.72	0	1
	10	7.49	1.39	7.01	0.87	2	0	7.30	1.48	1	1	7.29	1.40	3	0	7.39	1.37	0	0
	11	7.44	1.39	7.29	1.32	0	0	7.29	1.27	3	3	Missing	Missing	1	3	Missing	Missing	0	0
	12	7.44	1.33	7.29	1.23	1	0	Missing	Missing	0	0
	13	7.43	1.47	7.26	1.23	0	0	7.14	1.27	3	2	Missing	Missing	0	0
	14	7.45	1.36	7.35	1.24	0	0	7.48	1.18	0	0	7.47	1.11	0	0	Missing	Missing	0	0

Three cohorts of swine underwent related experiments using the same method of hypoxic injury. Cohorts 1 (N = 48 total rounds) and cohort 2 (N = 15 total rounds) did not receive ionized calcium treatments. Cohort 3 (N = 37 Ca++ boluses) received ad hoc ionized calcium in 9 of the 14 experiments. Cohorts 2 and 3 underwent a maximum of 4 experimental rounds, whereas cohort 1 underwent a maximum of 5. Blank entries indicate the animal did not survive to that round of experiment. Some blood gas data was missing, which is labeled accordingly