Table 2.
Associations between continuous estradiol (unit of analysis is per SD on the natural log scale) and separate inflammation biomarkers that were statistically significant (p < 0.05) in models where the inflammation biomarker was natural log transformed and standardized (linear model) or ordered categories (ordinal model)
| Linear model results |
Ordinal model results |
|||
|---|---|---|---|---|
| SD changea | 95% CI | ORb | 95% CI | |
| Biomarkers associated with estradiol in both the linear and ordinal models | ||||
| CRP | 0.314 | (0.140, 0.487) | 1.90 | (1.23, 2.96) |
| Adiponectin | −0.216 | (−0.412, −0.020) | 0.49 | (0.32, 0.76) |
| CXCL6 | −0.255 | (−0.455, −0.055) | 0.66 | (0.45, 0.97) |
| TARC | −0.301 | (−0.499, −0.104) | 0.66 | (0.45, 0.97) |
| Eotaxin-1 | −0.285 | (−0.480, −0.089) | 0.56 | (0.36, 0.83) |
| PAI-1 | 0.239 | (0.024, 0.453) | 1.64 | (1.09, 2.46) |
| SAA | 0.201 | (0.098, 0.393) | 1.63 | (1.10, 2.42) |
| Biomarkers nominally associated with estradiol in only the linear model | ||||
| IL12(p70) | −0.196 | (−0.387, −0.006) | ||
| Biomarkers nominally associated with estradiol in only the ordinal model | ||||
| SAP | 1.66 | (1.11, 2.47) | ||
| sIL-1RII | 1.83 | (1.20, 2.77) | ||
| Resistin | 1.53 | (1.04, 2.26) | ||
| CCL21 | 1.49 | (1.01, 2.18) | ||
| FGF-2 | 1.52 | (1.01, 2.28) | ||
| IL6 | 1.50 | (1.00, 2.24) | ||
SD standard deviation, OR odds ratio, CI confidence interval, CRP C-reactive protein, CXCL6 chemokine (C-X-C motif) ligand-6, TARC thymus activation-regulated chemokine, Eotaxin-1 eosinophil chemotactic protein, PAI-1 plasminogen activator protein-1, SAA serum amyloid A, IL12(p70) interleukin-12(p70), SAP serum amyloid P, sIL-1RII soluble IL-1 receptor 2, CCL21 chemokine (C–C motif) ligand-21, FGF2 basic fibroblast growth factor, IL-6 interleukin-6
The SD change is the standard deviation (SD) change in the geometric mean of the respective inflammation biomarker per SD change in the geometric mean of estradiol; the corresponding study levels are: −2 SD = 1.86 pg/ml; −1 SD = 3.85 pg/ml; study mea n = 7.96 pg/ml; +1 SD = 16.45 pg/ml; +2 SD = 34.01 pg/ml
The OR is interpreted as the odds of increasing to the next inflammation ordered quartile category per SD change in the geometric mean of estradiol