Table 2.

Inclusion and exclusion criteria

Inclusion	Exclusion
English-language articles German-language articles	Articles in other languages
All kinds of studies evaluating big data analysis techniques	Big cohort studies examining data from electronic health records
Big data as computational analysis of extremely large data sets to find patterns, trends and associations	Studies using classical statistics programs
Patients with polypharmacy (more than 3 medications)	Patients consuming less than 3 medications
Big data analysis techniques to identify patients with polypharmacy as well as drug interactions or adverse drug events in patients on multiple medications were included	Studies focusing on identifying new drug-drug interactions or new drug combinations