Table 3.

Impact of half-life clearance of plasma EBV DNA on various prespecified survival endpoints.

	Half-life clearance of plasma EBV DNA
	Half-life ≤15 days	Half-life >15 days	P
Distant Metastasis-Free Survival			0.009
3-years rate	85.0%	31.3%
95% confidence interval	72.8–97.2%	0–77.7%
Median (months)	NR	31.20
95% confidence interval	NA	0.93–61.47
Mean (months)	66.17	24.41
95% confidence interval	59.67–72.68	15.09–33.94
Progression-Free Survival			0.005
3-years rate	79.5%	25.0%
95% confidence interval	65.9–93.2%	0–63.7%
Median (months)	NR	22.70
95% confidence interval	NA	3.88–41.52
Mean (months)	62.66	23.04
95% confidence interval	55.00–70.32	14.15–31.93
Overall Survival			0.024
3-years rate	91.3%	75.0%
95% confidence interval	82.0–100%	45.0–100%
Median (months)	NR	38.63
95% confidence interval	NA	16.85–60.42
Mean (months)	69.61	37.48
95% confidence interval	64.68–74.55	25.80–49.15

NA, not available; NR, not reached.