TABLE 2.
Pharmacokinetic parameters of midazolam and 1-OH-midazolam.
| MZ | DZ | |
| Midazolam | ||
| AUC [μg * min/L] | 450.3 (290.3 – 897.4) | 431.0 (287.8 – 640.7) |
| AUC420 [μg * min/L] | 378.6 (255.8 – 636.4) | 354.8 (240.0 – 542.9) |
| Cl [L/min] | 0.45 (0.23 – 0.69) | 0.48 (0.32 – 0.70) |
| Cl [ml/min/kg] | 6.80 (3.02 – 11.80) | 6.74 (4.94 – 10.27) |
| t1/2 [min] | 163 (97 – 552) | 185 (102 – 505) |
| Cmax [μg/L] | 4.11 (2.71 – 9.00) | 3.76 (2.34 – 6.88) |
| tmax [min] | 10 (9 – 20) | 10 (10 – 19) |
| 1-OH-midazolam | ||
| AUC [μg * min/L] | 66.88 (33.75 – 195.6) | 73.31 (30.95 – 322.8) |
| Ratio 1-OH-midazolam/midazolam (AUC) | 0.15 (0.09 – 0.61) | 0.17 (0.07 – 0.54) |
Data is given in median (minimum – maximum). AUC, Area under the concentration time curve extrapolated to infinity; AUC420, Area under the concentration time curve from 0 to 420 min after midazolam administration; Cl, total body clearance; t1/2, terminal elimination half-life; Cmax, maximum concentration; tmax, time of maximum concentration.