TABLE 6.
Phenotypic correlation, genetic correlation, non-shared correlation, and bivariate heritability of 4 biomarkers of CYP3A activity.
| Midazolam | 1-OH-midazolam | 4ß-OH-cholesterol | 6ß-OH-cortisol | |
| Phenotypic correlations (rph) | ||||
| Midazolam | 1 | 0.37 (0.07)* | −0.24 (0.07)* | −0.41 (0.06)* |
| 1-OH-midazolam | 1 | 0.01 (0.08) | −0.13 (0.08) | |
| 4ß-OH-cholesterol | 1 | 0.26 (0.07)* | ||
| 6ß-OH-cortisol | 1 | |||
| Genetic correlations (rg) | ||||
| Midazolam | 1 | 0.37 (0.09)* | −0.18 (0.11) | −0.42 (0.10)* |
| 1-OH-midazolam | 1 | 0.04 (0.09) | −0.15 (0.10) | |
| 4ß-OH-cholesterol | 1 | 0.11 (0.11) | ||
| 6ß-OH-cortisol | 1 | |||
| Non-shared correlation (re) | ||||
| Midazolam | 1 | 0.54 (0.08)* | −0.43 (0.09)* | −0.38 (0.09)* |
| 1-OH-midazolam | 1 | −0.23 (0.10)* | −0.07 (0.11) | |
| 4ß-OH-cholesterol | 1 | 0.69 (0.06)* | ||
| 6ß-OH-cortisol | 1 | |||
| Bivariate heritability | ||||
| Midazolam | 1 | 0.78 (0.07)* | 0.52 (0.19)* | 0.68 (0.11)* |
| 1-OH-midazolam | 1 | 3.19 (14.89) | 0.92 (0.13)* | |
| 4ß-OH-cholesterol | 1 | 0.30 (0.23) | ||
| 6ß-OH-cortisol | 1 | |||
Estimates (standard errors) * Significant to 95% of confidence. For midazolam and 1-OH midazolam, AUC was used in structural equation modeling as presented here.