Figure 1.

Mitochondrial quality control. Under normal circumstances, mitochondria are tubular in shape and are damaged when subjected to certain pressures. Damaged mitochondria can be released from a healthy mitochondrial network by splitting. Healthy mitochondria return to the mitochondrial network through fusion, and some mitochondria which are temporarily depolarized or not seriously damaged are also fused into the mitochondrial network after repair. The remaining permanent depolarized and irreversibly damaged mitochondria were removed by autophagy.