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. 2020 Aug 21;11:1992. doi: 10.3389/fmicb.2020.01992

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Copyright © 2020 Ren, Zhang, Ding, Zhong, Hu, Xu and Deng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The RIG-I-like receptors (RLRs) antiviral signaling pathway. After the virus invades the body, RLRs recognizes the viral RNA and interacts with mitochondrial antiviral signaling (MAVS) to activate it. Then, it transduces the signal to the downstream TNF receptor associated factor 2/6 (TRAF2/6) and TRAF3, further activates IκB kinases (IkK complex) and TANK-binding kinases (TBK1) complex and nuclear transcription factor κB (NF-κB) and interferon regulatory factor 3 (IRF3), and induces the expression of various proinflammatory factors and interferon and finally produces an efficient antiviral immune response.