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. Author manuscript; available in PMC: 2021 Aug 20.
Published in final edited form as: Cell Chem Biol. 2020 Aug 13;27(8):904–920. doi: 10.1016/j.chembiol.2020.07.022

Figure 6. Luciferase-rhodopsin fusions enable spatiotemporal control over ion channel function.

Figure 6.

(A) The first-generation luminopsin (LMO1) featured Gluc (blue) tethered to channelrhodopsin2 (ChR2, green). CTZ application potentiates energy transfer, driving retinal isomerization and channel opening. (B) LMO1 was expressed in HEK cells. CTZ application generated photocurrents. Reprinted from Berglund, et al. 2013.