Table 2.
Genes related to pathways associated with cancer. PMIDs of the studies that relate to role of the pathway in melanoma and gene-count before and after univariate Cox-PH analysis is provided.
| S. no. | Pathway | PMID | No. of Genes | No. of GPM | No. of BPM | Combined |
|---|---|---|---|---|---|---|
| 1 | NRF2 | 27344172, 18353146 | 481 | 27 | 26 | 53 |
| 2 | P53 | 32377702, 31374895 | 201 | 17 | 16 | 33 |
| 3 | Apoptosis | 32687246, 32645331 | 161 | 29 | 4 | 33 |
| 4 | WNT | 32659938, 32073511 | 151 | 7 | 9 | 16 |
| 5 | CELL-CYCLE | - | 128 | 4 | 17 | 21 |
| 6 | PI3K-AKT | 32626712, 32558531 | 105 | 18 | 11 | 29 |
| 7 | TGF-β | 31667872, 31599708 | 86 | 3 | 1 | 4 |
| 8 | NOTCH | 30569717, 30941830 | 47 | 3 | 4 | 7 |
| 9 | MYC | 32283126 | 25 | 2 | 2 | 4 |
| 10 | RAS | 32605090, 32568870 | 23 | 2 | 1 | 3 |
| 11 | HIPPO | 32407182, 32561850 | 22 | 1 | 2 | 3 |