Table 3.

MLR models for risk stratification. The table shows the best models for each pathway and corresponding gene set used. Patients with predicted OS less than or equal to the median cutoff are at higher risk than patients with predicted OS more than cutoff.

S. no.	Pathway	Gene set	Regressor	HR	p-val	C
1	NRF2	Combined	Ridge	2.17	3 × 10−6	0.60
2	P53	Combined	RF	2.04	1 × 10−5	0.59
3∗	Apoptosis	GPM	RF	2.24	1.2x10−6	0.59
4	WNT	Combined	RF	2.22	2 × 10−6	0.59
5	CELL-CYCLE	Combined	RF	1.76	5.7 × 10−3	0.59
6	PI3K-AKT	Combined	RF	1.90	8 × 10−5	0.60
7	TGF-β	Combined	KNN	1.73	9 × 10−4	0.58
8	NOTCH	Combined	Lasso	2.34	3 × 10−7	0.62
9	MYC	GPM	Lasso	1.68	1.7 × 10−3	0.57
10	RAS	Combined	Lasso	1.79	3.8 × 10−4	0.58
11	HIPPO	Combined	KNN	1.11	0.51	0.52
12∗	Apoptosis + NOTCH	GPM + Combined	RF	2.54	2.3x10−8	0.61

∗Boldface indicates the best results. Hyperparameters for above models are provided in Supplementary S1 TableC.