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. 2020 Aug 21;11:1015. doi: 10.3389/fphys.2020.01015

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Copyright © 2020 Antequera-González, Martínez-Micaelo and Alegret.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical abstract of the review: a heart is represented at the left, signalizing the aorta, as well as the zone where the aortic valve is found. Different morphologies of this valve are also shown, pointing out the generalities of a healthy tricuspid aortic valve (TAV) and bicuspid aortic valve (BAV) disease. Additionally, endothelial dysfunction (ED) and its importance in BAV disease are also discussed. TAV, Tricuspid aortic valve; BAV, Bicuspid aortic valve; Notch-1, Neurogenic locus Notch homolog protein 1; ROBO4, Roundabout guidance receptor 4; GATA4, GATA binding protein 4. The figure was created by using pictures from Servier Medical Art (http://smart.servier.com/), licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/).