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. 2020 Jun 11;2(2):fcaa065. doi: 10.1093/braincomms/fcaa065

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© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Group-specific seeding patterns associated with distinct genetic predictors. Scatterplots of regional Parkinson’s disease-related gene expression versus average seed region likelihood for (A) all GWAS Parkinson’s disease risk-factor genes, (B) immune-related genes, (C) lysosomal genes, (D) autophagy-related genes, (E) mitochondrial genes and (F) LAG3. The S1 seeds are predicted by the average of all GWAS genes, immune-related and lysosomal genes, whereas S2 genes are predicted by autophagy-related genes and LAG3. (G) Scatterplots of regional microglial and neuronal abundance quantified by PC1 of high-fidelity genes, versus average seed region likelihood. Increased microglial abundance and decreased neuronal abundance predict S2 seed regions, while these measures are unrelated to S2 seed region likelihood.