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. 2020 Jun 8;2(2):fcaa077. doi: 10.1093/braincomms/fcaa077

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© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Group average fractional anisotropy and microscopic anisotropy. (A) Left: group FA averages within the whole-brain NAWM; middle: FA group averages within a slab of NAWM; right: μFA group averages within a slab of NAWM. Error bars indicate standard error of the mean. (B) FA (left panel) and μFA (right panel) histograms of NAWM. The histograms were estimated within each subject and then averaged within groups. (C) Imaging slap where microscopic fractional anisotropy was acquired. RRMS = relapsing-remitting multiple sclerosis; PPMS = primary-progressive multiple sclerosis.