Figure 2.

Treg suppressive function on Tresp proliferation. CD4⁺CD25^highTregs were co-cultured with CD4⁺CD25^neg Tresps and proliferation was determined by ³H-thymidine incorporation. (A) No correlation between age and suppressive activity of Tregs on Tresp proliferation (1:1 ratio) was noted. (B) Suppression (%) of Tregs on Tresp proliferation in MCI vs. HC in 1:1 and 2:1 Tresps: Tregs ratios were comparable. Suppression of Tregs on Tresps proliferation in Alzheimer’s disease in both 1:1 and 2:1 Tresps: Tregs ratios were reduced compared with both MCI and HC. P-values are *P < 0.05, **P < 0.01, and ***P < 0.001.