Figure 3.

Treg immunophenotype and suppressive function following ex vivo expansion. (A) In a second group of individuals, suppression (%) of CD4⁺CD25^highTregs on Tresp proliferation (1:1 ratio) at baseline (base) was compromised in Alzheimer patients (n = 10), compared with HC (n = 10). Following 10 days of ex vivo expansion, amplified suppressive function of expanded (exp) Tregs on Tresp proliferation was noted in all groups. CD25 (B) and FoxP3 (C) MFIs in CD4⁺CD25^highTreg population were elevated following ex vivo expansion. P-values are *P< 0.05, **P< 0.01 and ***P< 0.001.