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The suppressive mechanism of ex vivo expanded Tregs. Expanded Tregs of Alzheimer patients (n = 4) (A) and HC (n = 4) (B) were co-cultured with pro-inflammatory macrophages (M1) and relative fold change of IL6 protein (% of M1-only) were assayed in the presence of IL13 or CD25 neutralizing antibodies (IL13 NA and IL25 NA) or transwells. The absence of direct cell−cell contact by using transwells, blocked suppressive function of ex vivo expanded Tregs. P-values are **P < 0.01.
