Scheme 1.

Scheme depicting the effect of aerobic conditions and H₂O₂reaction on cofilin-2 WT and its S3D mutant. Purified cofilin aggregates over time. Cofilin unphosphorylated and phosphorylated are represented by their isosurfaces of electrostatic potential (in blue: positive potential, in red: negative). Under oxidative stress the phosphomimetic form of cofilin progresses towards the formation of amyloid fibers, whereas the WT maintains the aggregation path found under aerobic conditions. Sulfide prevents the formation of both large aggregates as well as amyloid fibers in the WT and S3D.