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. 2020 Aug 21;10:1608. doi: 10.3389/fonc.2020.01608

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Copyright © 2020 Sun, Yang, Wang, Liu, Hou, Lu, Chen, Zhang, Zhou, Mo and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The influence of HER2 on self-renewal ability in GCSCs was examined by sphere formation assay. Representative pictures were taken at ×400 magnification, and scale bars represent 40 μm. Pictures (A,C) are GCSC sphere of GCSC3-shHER2 and GCSC3-shCtrl, respectively. Pictures (B,D) are non-sphere formation GCSC of GCSC3-shHER2 and GCSC3-shCtrl, respectively. The results showed that down-regulation of HER2 could decrease the self-renewal ability in GCSCs (77.36% vs. 56.45%, p = 0.029), *p < 0.05.