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. 2020 Aug 21;10:1608. doi: 10.3389/fonc.2020.01608

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Copyright © 2020 Sun, Yang, Wang, Liu, Hou, Lu, Chen, Zhang, Zhou, Mo and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The results of CCK-8 assay, chemotherapy sensitivity, and xenograft models of GCSCs. Picture (A) shows that down-regulation of HER2 could decrease the proliferation of GCSCs (p = 0.0338). Data were expressed as mean ± SEM. Pictures (B,C) show that the chemotherapy sensitivity for oxaliplatin and 5-fluorouracil was increased after HER2 interference (p < 0.0001). Pictures (D,E) show that tumor weight in the GCSC3-shCtrl group was significantly lower than that in the GCSC3-shHER2 group (0.12 ± 0.04 g vs. 0.32 ± 0.06 g, p = 0.0192), *p < 0.05.