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. 2020 Aug 21;10:1608. doi: 10.3389/fonc.2020.01608

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Copyright © 2020 Sun, Yang, Wang, Liu, Hou, Lu, Chen, Zhang, Zhou, Mo and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival analyses and results of gene microarray and signaling pathway analysis. Picture (A) X-tile plots for serum concentration of HER2 in our study; the red spot shows the cutoff value (11.6 ng/ml) that separates the cohort into two groups. Picture (B) Survival analyses of patients with different serum concentrations of HER2; the result indicated that patients with high concentration of HER2 in serum had a favorable prognosis (p = 0.0336). Picture (C) Survival analyses of patients with different expression levels of HER2 in tumor tissue (p = 0.4091). Picture (D) Heatmap representation of the gene expression profiles of HER2-interfered GCSCs and control cells. Up-regulated expressions are marked in red; down-regulations are colored green; black reflects no difference in expression levels. Picture (E) The volcano plot of the gene microarray is used to evaluate the overall distribution of the differential gene between the HER2-interfered GCSCs and control cells. Green plots represent down-regulation mRNA genes while red plots represent up-regulation mRNA genes with a fold change > 1.2 and p value < 0.05. Picture (F) Signaling pathway analysis revealed that HER2 gene might regulate the signal transduction of mTOR, Jak-STAT, and other signal pathways. Yellow circles represent pathways with up-regulation and down-regulation mRNA genes. Pathways that only contain up-regulation mRNA genes were marked with a red circle, while the blue one represents pathway that involves down-regulation mRNA genes. The size of circles shows the value of degree.