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. 2020 Aug 21;14:899. doi: 10.3389/fnins.2020.00899

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Copyright © 2020 Gelot and Represa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Developmental changes of TSC lesions. (A) Schematic representation of the main changes observed in fetal TSC lesions. Dysmorphic cells are represented in green (Giant cells) orange (dysmorphic astrocytes) and blue (dysmorphic neurons). MZ, marginal zone; CP, cortical plate; IZ, intermediate zone; SVZ, subventricular zone; VZ, ventricular zone. (B) Schematic representations suggesting that TSC lesions would be mosaic and result for the development of two different neural progenitors: from pallium (light blue) and subpallium (violet). This hypothesis is supported by our data indicating that a subgroup of dysmorphic neurons and Giant cells express markers of GABA interneurons and that part of tuber cells would enter from the marginal zone. As only some cells display dysplastic features, we speculate that TSC mutation impact the developmental program of subset of cell lines (tagged with X or triangle).