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. 2020 Sep 4;183(2):429–441.e16. doi: 10.1016/j.cell.2020.09.007

Figure 1.

Figure 1

Binding of VH ab8 and VH-Fc ab8 to Recombinant SARS-CoV-2 RBD and S1 Proteins and Cell Membrane-Associated S

(A and D) VH and VH-Fc ab8 binding to recombinant RBD and S1 proteins measured by ELISA. The MERS-CoV antibody IgG1 m336 was used as a negative control. Experiments were performed in duplicate and the error bars denote ± SD, n = 2. (D) shows concentration-dependent binding of VH-Fc ab8 and ACE2-Fc to 293T-S cells.

(B and E) Kinetics of VH ab8 (B) and VH-Fc ab8 (E) binding to RBD.

(C) Binding of VH-Fc ab8, ACE2-Fc, and IgG1 CR3022 to S transiently transfected 293T cells (293T-S). The 293T cells without transfection serve as a control. Antibodies or proteins were evaluated at a concentration of 1 μM.

See also Figure S2A.