Figure 7.

Increased RBC ω-3 HUFA scores correlate with reductions in a broad array of autoantibodies relative to specificity and isotype in the plasma and BALF of cSiO₂-treated NZBWF1 mice. Autoantigen coated protein arrays were used for profiling four isotypes of autoantibody (IgG, IgM, IgA, and IgE) in plasma and BALF in Study 2. The final intensity value of each autoantibody was expressed as an autoantibody score. Individual autoantibodies were grouped according to the function of their cognate antigens (group names shown on y-axis) as described in the Methods section. The scores of each autoantibody in this group were combined to obtain an overall score for each group. This score was related to the ω-3 HUFA score using Spearman's correlation coefficient. *p < 0.05, **p < 0.01, ***p < 0.001.