Figure 9.

Heightened O3Is correspond with suppression of leukocyte infiltration, ELS development, and disease progression in cSiO₂-triggered NZBWF1 mice. (A) Macrophage and (B) lymphocyte infiltration, as well as (C) B-cell, and (D) T-cell positive lung tissue were negatively correlated with the O3I. (E) Mice positive for renal lesions and elevated plasma anti-dsDNA IgG (significantly different from mean of the Veh-treated group, p < 0.05) had significantly lower median Omega-3 Indexes than mice in the the group negative for these endpoints, as assessed by the non-parametric Mann-Whitney U-test (***p < 0.001). For (A–D), data were analyzed by a simple linear regression and goodness of fit presented as R². Regression coefficients were considered statistically significant at p < 0.05. Shaded bands around regression lines represent 95% confidence intervals.