Table 2. Association between overall survival and the metabolism-related-gene signature comprising nine genes, in hepatocellular carcinoma patients in the ICGC cohort.
| Parameter | ICGC cohort | ||
|---|---|---|---|
| Number (High/Low) | HR (95% CI) | P-value | |
| Total | 130/100 | 5.22 (2.82–9.68) | <0.001 |
| Age | |||
| ≤65 | 45/44 | 5.58 (1.55–20.11) | 0.009 |
| >65 | 85/56 | 6.47 (1.93–21.72) | 0.002 |
| Gender | |||
| Male | 93/76 | 4.51 (1.66–12.25) | 0.003 |
| Female | 37/24 | 12.41 (1.64–94.14) | 0.015 |
| LCSGJ stage | |||
| Stage I | 22/15 | 1.00 (0.82–1.22) | 0.999 |
| Stage II | 59/41 | 2.68 (0.98–7.36) | 0.056 |
| Stage III and IV | 51/45 | 17.68 (2.31–135.11) | 0.006 |
Notes.
- HR
- hazard ratio
- CI
- confidence interval
- LCSGJ
- Liver Cancer Study Group of Japan