Figure 1.

Anatomical, neurochemical, and connectome-based characterizations of the mesencephalic locomotor region (MLR). Schematic summaries of (A) major inputs and outputs of the CnF and PPN in rodents, (B) anatomical electrical mapping of the MLR in cats from Takakusaki et al. (2016); (C) CnF and PPN vGlut2+ photostimulation results from Josset et al. (2018) and (D) cell-type-specific functional characterizations of the CnF and PPN reported in the literature. Abbreviations: ChAT, choline acetyltransferase; CnF, cuneiform nucleus; IC, inferior colliculus; PAG, periaqueductal gray; PPN, pedunculopontine nucleus; SC, superior colliculus; SCP, superior cerebellar peduncle; vGAT, vesicular GABA transporter; vGlut2, vesicular glutamate transporter 2. *Denotes behavioral effects elicited from subsets of a neurochemical population projecting to specific targets.