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. 2020 Aug 21;14:64. doi: 10.3389/fnsys.2020.00064

Figure 2.

Figure 2

Three-dimensional reconstructions of the human MLR and regional anatomy. Reconstructions were made using Lead-DBS and available MNI-space subcortical atlases (Horn and Kühn, 2015). A separate CnF NIfTI object (cyan) was created in MATLAB in relation to the PPN (purple) based on Olszewski and Baxter (1982). (A) A parasagittal projection (5 mm lateral to the midline) of the CnF and PPN is overlaid with active contacts from PPN DBS patients with poor (red), good (green), best (dark blue), and unevaluated (yellow) FOG outcomes from Goetz et al. (2019). (B) Sideview of 3D reconstruction of MLR and regional anatomy, with left ML and STT removed to show the CnF and PPN. (C) Diagonal view with right ML and STT removed, projected on to a transverse slice of the brain at the level of the pons. Abbreviations: CnF, cuneiform nucleus; CTT, central tegmental tract; dSCF, decussating superior cerebellar fibers; LC, locus coeruleus; ML, medial lemniscus; PPN, pedunculopontine nucleus; RN, red nucleus; STT, spinothalamic tract.