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. 2020 Aug 21;11:1891. doi: 10.3389/fimmu.2020.01891

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Copyright © 2020 Greer, Trifilieff and Pender.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Significantly elevated levels of isotype-switched anti-PLP antibodies are present in MS patients. (A) Reactivity in ELISA of healthy individuals' (HC), MS and OND patients' sera (all tested at 1/40 dilution) to PLP_181−230, synthesized with 2 disulphide bonds to mimic the structure of the second extracellular loop of PLP. Results are presented as the normalized PLP_181−230-specific absorbance values. Analyzed using Kruskal–Wallis test with Dunn's multiple comparison test. (B) Percentage of samples of each isotype from individuals with elevated (at or above the 75th percentile of the HC group) antibodies reactive to PLP. n.s., not significant.