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. 2020 Aug 5;24(4):189–196. doi: 10.1080/19768354.2020.1804445

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Inhibition of TRPM7 prevents trans-dedifferentiation of Schwann cells in ex vivo sciatic nerves. (A,B) Sciatic nerve fibers were immunostained with anti-S100 (green), anti-lysosomal-associated membrane protein (LAMP)-1 and anti-p75 neurotrophin receptor (p75NTR). Scale bar = 50 μm. (C) Relative intensities quantified the increase of LAMP1 and p75NTR expression in ex vivo trans-dedifferentiated Schwann cell (n = 3). (D) Western blot analysis showed protein expression of TRPM7 and p75NTR in ex vivo sciatic nerves. (E) Relative intensities indicated the effects of TRPM7 inhibition on trans-dedifferentiation (n = 9).