Table 2. Demographic characteristics, clinical data, and therapeutic regimens for children of Balamuthia mandrillaris Infection.

Patient	Age, years	Sex	Region	Presenting clinical symptoms	Mode of diagnosis	Outcome	Reference
1	14	M	Venezuela	CNS:seizures and weakness on right arm and leg	Autopsy	died	[3]
2	1.5	M	California	CNS:Ataxia,cranial nervepolsy,vestibular cerebellar nystagmus	Serology,indirect immunofluorescence,PCR(brain)	died	[4]
3	3	F	California	CNS:Seizures,emesis	indirect immunofluorescence,PCR (brain,CSF)	died	[5]
4	7	M	California	CNS:Headache,focal seizures,cranial nerve palsy	Serology(brain)	died	[4]
5	7	M	California	CNS:Headache,neck stiffness,seizures, lethargy,cranial nerve palsy(XIth)	indirect immunofluorescence, PCR(CSF)	died	[4]
6	12	M	California	CNS:Headache,emesis,altered mental status	indirect immunofluorescence, PCR(brain)	died	[4]
7	schoolage	F	Spain	skin:cutaneous lesions on the face; CNS:progressive neurological involvement	brain necropsy	died	[6]
8	3	M	czech republic	CNS:tiredness,seizures,unconscious	brain biopsy	died	[7]
9	3	F	California	CNS:fatigue,emesis,tonic-clonic seizures,coma	Indirect immunofluorescencetest;brain necropsy	died	[8]
10	2	F	California	CNS:headache,lethargic,right-sided hemiparesis	brain necropsy	died	[6]
11	7	M	California	CNS:focal seizures,wide based gait,right cranial nerve, change in personality, lethargic	brain biopsy	died	[6]
12	2.5	M	texas	CNS:emesis,ataxia,seizures	CSF and serum for Balamuthia antibody titer	died	[6]
13	11	M	texas	CNS:vomiting,progressive lethargy,clumsiness,right hemiparesis,focal seizure	brain biopsy	died	[9]
14	0.6	F	Australia	CNS:seizures,left-sided weakness,	brain necropsy,immunofluorescent	died	[10]
15	6	F	Vermont	CNS:headache,stiff neck, nausea and vomiting	brain biopsy,immunofluorescent	died	[11]
16	5	M	Australia	Skin:mid facial granulomatous lesion; CNS:right sixth-nerve palsy,ataxia, nystagmus.	brain biopsy	died	[12]
17	8	M	Portugal	CNS:headache,vomiting,lethargy,	brain biopsy, PCR	died	[13]
18	2	F	Arizona	CNS:intermittent disequilibrium and worsening gait	brain biopsy	died	[14]
19	7	M	Peruvian	skin:asymptomatic papule on the dorsum of the nose; CNS:neurologic changes	skin biopsy	died	[15]
20	12	M	Argentina.	CNS:lethargy,right body hemiparesis	brain biopsy, Indirect immunofluorescencetest	died	[16]
21	5	M	Argentina.	Skin:nonspecific granulomatous lesions; CNS:clonic upper limb seizures, loss of consciousness	brain biopsy (histopathologic examination, Immunofluo)	died	[14]
22	3	F	Argentina.	CNS:clonic partial seizures,profound deterio ration in level of consciousness	brain biopsy (immunofluorescence)	died	[14]
23	6	M	Argentina.	skin:cutaneous lesions in the face; CNS:right body hemiparesis and consciousness deterioration	brain biopsy (Neuropathologic examination, immunofluorescence)	died	[14]
24	6	M	Pennsylvania	CNS:lethargy, hallucinations, ataxia, diplopia, nystagmus, and cranial nerve palsy	mNGS (CSF)	died	[17]
25	5	F	California	CNS:generalized seizures	brain biopsy (immunofluorescence)	survived	[18]
26	4	F	Georgia	CNS:headache,intermittent gait abnormality,lethargy,occasional seizures	brain biopsy (immunofluorescence)	died	[19]
27	13	F	Arizona	CNS:headache,left hemiparesis,Coma	brain biopsy (Histopathology)	died	[20]
28	4	M	Mississippi	CNS:Personality changes, loss of appetite, muscle twitching, headache, seizure	Autopsy	died	[21]
29	4	F	Thai	CNS:headache,ataxia	PCR (csf)	died	[22]
30	2	F	Arizona	CNS:ataxia,irritability,lethargy	Autopsy	died	[23]