Table 3. Mutations detected across drug resistance associated genes in GC1 and GC2 isolates.
| Druga | Gene | GC1 (n = 121) | GC2 (n = 39) |
|---|---|---|---|
| INH | ahpC | G-48A (n = 1) | |
| inhA | C-15T (n = 4); C-34T (n = 4); T-8G (n = 2); S94A (n = 1) | ||
| katG | S315T (n = 121) | S315T (n = 39) | |
| RIF | rpoB | 1349delCGinsTC (n = 18); 1365del3bp (n = 1); A286V (n = 1); A584G (n = 2); R827C (n = 5); D435G (n = 2); E761G (n = 1); G836S (n = 1); H835P (n = 1); I480V (n = 13); I491V (n = 4); L452P (n = 6); L731P (n = 12); P45S (n = 2); S450L (n = 78); V496A (n = 6) | S450L (n = 39) |
| STR | gidB | E92D (n = 121) | E92D (n = 39) |
| rpsL | K43R (n = 121) | K43R (n = 39) | |
| EMB | embA | C-12T (n = 1) | N722D (n = 1); C-16G (n = 11) |
| embB | N296H (n = 4); D1024N (n = 1); D354A (n = 8); Q497R (n = 14); Q497K (n = 3); G406A (n = 5); G406D (n = 4); G406C (n = 1); G406S (n = 1); M306I (n = 28); M306V (n = 38); T643I (n = 1); Y319C (n = 2) | M306V (n = 37); Y319S (n = 1) | |
| ubiA | I179T (n = 4); W175G (n = 1) | T104A (n = 1) | |
| PZA | pncA | 260insCC (n = 1); 390delC (n = 2); D12A (n = 2); D136Y (n = 1); D63A (n = 6); Q141P (n = 17); G108R (n = 1); G17V (n = 1); G78D (n = 1); G97V (n = 1); H57R (n = 3); L116P (n = 1); L151S (n = 4); L172P (n = 1); L4S (n = 13); L4W (n = 2); M1I (n = 1); M1T (n = 1); T114P (n = 1); T168P (n = 1); T47A (n = 2); W68R (n = 1); W68G (n = 1); Y64D (n = 2); V139G (n = 1); V180A (n = 6); V7G (n = 2); A-11G (n = 2); G-13T (n = 2) | 188delG (n = 4); 352insG (n = 2); D63A (n = 11); G132S (n = 2); H51Y (n = 1); I133T (n = 1); I6S (n = 2); L156P (n = 1); K96T (n = 1); V139L (n = 1); V155G (n = 1); V163E (n = 1) |
| FQ | gyrA | 280del5bpins5bp (n = 1); 281del4bpins4bp (n = 13); A90V (n = 5); E21Q (n = 121); G668D (n = 121); H52Y (n = 1); S447F (n = 4) | 280del5bpins5bp (n = 1); 281del4bpins4bp (n = 7); E21Q (n = 39); G668D (n = 39) |
| SLID | eis | C-12T (n = 3); C-14T (n = 3); G-10A (n = 10); G-37T (n = 19) | C-12T (n = 1); C-14T (n = 4); G-10A (n = 1) |
| rrs | A1401G (n = 16) | A1401G (n = 8) | |
| ETH | ethA | 1012delA (n = 7); 113delT (n = 9); 511delT (n = 3); 705delA (n = 2); 828delC (n = 2); 887delA (n = 6); L440P (n = 5); F64V (n = 1); W256Ter (n = 2); Y140Ter (n = 2); Y461C (n = 1) | 182delG (n = 11); 945delG (n = 1); R207G (n = 2); Q254P (n = 1); Q347Ter (n = 2); L62R (n = 4); T314I (n = 9); W391Ter (n = 2) |
| inhA | C-15T (n = 4); C-34T (n = 4); T-8G (n = 2); S94A (n = 1) | ||
| DCS | alr | S22L (n = 1) | |
| PAS | folC | I43T (n = 2); S150G (n = 1) | E40G (n = 1) |
| thyA | 654delC (n = 1) | P253A (n = 12) | |
| thyX | C-16T (n = 1); C-19G (n = 1) | C-16T (n = 11) |
aDrug abbreviations: INH, isoniazid; RIF, rifampicin; STR, streptomycin; EMB, ethambutol; PZA, pyrazinamide; FQ, fluoroquinolones; SLID, second-line injectable drugs; ETH, ethionamide; DCS, D-cycloserine; PAS, para-aminosalicylic acid.