Table 2: Numbers and person-years of follow-up for risk factors or comorbidities across 129,650 dementia cases.
*Chronic kidney disease stages III-V. ICD-9, ICD-10 and Read V2 codes used to derive the variables are displayed in Supplementary Appendices 4-6. A detailed breakdown of the number of participants identified by each individual code is available in Supplementary Appendices 9-29 and at https://datashare.is.ed.ac.uk/handle/10283/3268.
| Risk factor / comorbidity | Dementia cases | ||
|---|---|---|---|
|
|
|||
| n | (%) | Person-years | |
| Ever-smoker | 67,775 | (52) | 1,070,030 |
| Obesity | 9,197 | (7) | 161,496 |
| Hypertension | 81,377 | (63) | 1,211,400 |
| Diabetes mellitus | 29,745 | (23) | 430,198 |
| Osteoporosis | 24,486 | (19) | 381,686 |
| Atrial fibrillation | 38,866 | (30) | 556,328 |
| Myocardial infarction | 22,194 | (17) | 310,403 |
| Heart failure | 31,703 | (24) | 426,072 |
| Peripheral arterial disease | 9,612 | (7) | 136,934 |
| Stroke | 32,240 | (25) | 427,974 |
| Depression | 39,130 | (30) | 587,340 |
| Parkinson’s disease | 9,845 | (8) | 128,771 |
| Epilepsy | 9,496 | (7) | 128,487 |
| Motor neurone disease | 332 | (0) | 4,284 |
| Asthma | 22,303 | (17) | 338,197 |
| Chronic obstructive pulmonary disease | 24,444 | (19) | 346,059 |
| Cancer | 34,663 | (27) | 496,564 |
| Rheumatoid arthritis | 5,597 | (4) | 82,091 |
| Hypothyroidism | 18,663 | (14) | 273,953 |
| Alcohol dependence | 6,289 | (5) | 89,684 |
| Substance misuse | 2,323 | (2) | 36,589 |
| Chronic kidney disease* | 26,821 | (21) | 447,895 |