Table 6.

Genetic alternations in primary brain tumors.

Number	Mutant genes	MSI	MMR	TMB (muts/Mb)	PD-L1 (%)
1	IDH1, MGMT	MSS	pMMR	3.48	–
2	MGMT	MSS	pMMR	3.48	–
3	IDH1, MGMT	MSS	pMMR	4.35	1
4	IDH1, MGMT	MSS	pMMR	3.48	<1
5	MGMT, EGFR, PTEN	MSS	pMMR	1.74	–
6	MGMT, IDH1, 1p/19q	MSS	pMMR	3.48	–
7	MGMT, BRAF, MDM2	MSS	pMMR	2.61	30
8	MGMT. IDH2, 1p/19q	MSI-H	pMMR	2.61	<1
9	MGMT, IDH1, 1p/19q	MSS	pMMR	3.48	–
10	MGMT, IDH1, TP53	MSS	pMMR	2.61	<1
11	MGMT, EGFR, PTEN, CDK4, CDKN2A	MSS	pMMR	4.35	40
12	MGMT	MSS	pMMR	0	1
13	H3F3A, TP53, CDKN2A, MDM2, ERBB2	MSS	pMMR	2.29	–
14	MGMT, IDH1, TP53, CDKN2A, MET, KIT, PDGFRA	MSS	pMMR	2.29	1
15	H3F3A, CDK4, MDM2, ARID1A	MSS	pMMR	2.29	<1
16	TP53, PDGFRA, ATM	MSS	pMMR	5.34	1
17	BRAF, CCNE1, ERBB2	MSS	pMMR	0	15
18	NF1, H3F3A	MSS	pMMR	3.05	<1
19	TP53	MSS	pMMR	0	<1
20	H3F3A, PIK3CA, MDM4	MSS	pMMR	1.1	1
21	MGMT, IDH1, TP53, MET	MSS	pMMR	1.53	<1