Table 1.
Baseline and Clinic Characteristics of 8 COVID-19 Patients on ECMO (up to May 20, 2020)
| Patient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
|---|---|---|---|---|---|---|---|---|
| Date of admission | 2 Feb | 28 Jan | 30 Jan | 1 Feb | 1 Feb | 22 Jan | 29 Jan | 5 Mar |
| Sex | Male | Male | Male | Male | Male | Female | Male | Male |
| Age (y) | 64 | 81 | 62 | 75 | 65 | 63 | 25 | 75 |
| Weight/BMI (kg) | 76/24.5 | 72/23.8 | 75/24.3 | 67/22.4 | 62/20.8 | 65/24.2 | 125/40.8 | 67/22.4 |
| Comorbidities | ||||||||
| Hypertension | Yes | Yes | Yes | Yes | ||||
| Diabetes | Yes | Yes | ||||||
| Cardiovascular disease | Yes | |||||||
| Malignancy | BC | |||||||
| Cerebrovascular disease | CI | |||||||
| COPD | Yes | |||||||
| Chronic kidney disease | MN | |||||||
| Murry index | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| RT-PCR | Positive | Positive | Positive | Positive | Positive | Positive | Positive | Positive |
| WBC count (×10⁹/L) | 8.03 | 8.40 | 9.92 | 9.56 | 5.26 | 11.31 | 4.06 | 15.64 |
| Neutrophil count (×10⁹/L) | 6.91 | 7.56 | 8.82 | 9.03 | 4.96 | 9.82 | 3.21 | 14.58 |
| Lymphocyte (×10⁹/L) | 0.64 | 0.62 | 0.61 | 0.29 | 0.18 | 0.74 | 0.65 | 0.63 |
| Plt (×10⁹/L) | 337 | 148 | 159 | 144 | 151 | 161 | 162 | 203 |
| ALT (U/L) | 19 | 70 | 64 | 20 | 16 | 63 | 57 | 84 |
| AST (U/L) | 18 | 61 | 53 | 30 | 33 | 44 | 121 | 54 |
| Creatinine (μmol/L) | 81.40 | 139.70 | 70.80 | 162.31 | 184.69 | 61.85 | 140.00 | 95.07 |
| Troponin I (pg/mL) | 0.022 | 0.067 | 0.033 | 0.257 | 0.080 | 0.072 | 0.038 | 0.087 |
| NT-proBNP (pg/mL) | 58 | 1251 | 675 | 227 | 1313 | 6312 | 34 | 62.63 |
| Procalcitonin (ng/mL) | 2.09 | 0.55 | 0.14 | 0.3 | 16.39 | 3.56 | 0.07 | 0.68 |
| C-reactive protein (mg/L) | 83.09 | 57.69 | 63.57 | 88.65 | 155.28 | 92.05 | 39.95 | 111.32 |
| CD4 (cell/ul) | 386 | 68 | 63 | 53.5 | 373 | 132 | 143 | 92 |
| CD8 (cell/uL) | 125 | 31 | 63 | 83 | 166 | 55 | 143 | 17 |
| IL-6 (pg/mL) | 61.37 | 481.00 | 70.63 | 182.50 | 199.28 | 53.95 | 230.16 | 387.82 |
| Time of mechanical ventilation before ECMO | 4 | 10 | 12 h | 13 | 4 | 21 | 5 h* 13* |
11 h |
| P/F before ECMO | 67 | 66 | 64 | 75 | 76 | 70 | 54 | 78 |
| Lactate (mmol/L) | 2.4 | 2.8 | 3.1 | 4.0 | 1.3 | 2.4 | 3.1 | 3.2 |
| Time of ECMO (d) | 40 | 47 | 47 | 37 | 22 | 33 | 8/10 | 16 |
| State by now | Discharged | Died | Discharged | Died | Discharged | Died | Died | Weaned† |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; BC, bladder cancer; CI, cerebral infarction; COPD, chronic obstructive pulmonary disease; ECMO, extracorporeal membrane oxygenation; FiO2, fraction of inspired oxygen; IL-6, interleukin 6; MN, membranous nephropathy; NT-proBNP, N-terminal-pro hormone B-type natriuretic peptide; PaO2, partial pressure of oxygen; P/F, partial pressure of oxygen/fraction of inspired oxygen ratio; Plt, platelet; RT-PCR, reverse transcription-polymerase chain reaction.
Patient 7 received extracorporeal membrane oxygenation twice, on January 30 and February 12.
Patient 8 weaned from extracorporeal membrane oxygenation and ventilated.