Table 1.

Established parameters of GI digestion in the TIM-1 for simulating digestive conditions of a healthy adult after meal intake.

	Gastric phase	Small intestinal phase
		Duodenum	Jejunum	Ileum
Start residue	Gastric enzyme solution: 5 g	Small intestinal electrolyte solution (SIES): 15 g Pancreatin solution: 15 g Bile: 30 g Trypsin solution (2 mg/cup): 1 cup	SIES: 40 g Pancreatin solution: 40 g Bile: 80 g	SIES: 160 g
pH/time (min)	6/0, 5.7/15, 4.5/45, 2.9/90, 2.3/120, 1.8/240	maintained at 6.4	maintained at 6.9	maintained at 7.2
Enzyme andfluid secretion	0.25 ml/min pepsin 0.25 ml/min lipase 0.25 ml/min of 1.5 M HCl if necessary	0.5 ml/min bile salts (4% during the first 30 min of digestion then 2%) 0.25 ml/min pancreatic solution 0.25 ml/min SIES 0.25 ml/min 1 M NaHCO3 if necessary	10 ml/min jejunal fluid solution 0.25 ml/min 1 M NaHCO3 if necessary	10 mL/min ileal fluid solution 0.25 ml/min 1 M NaHCO3 if necessary