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. Author manuscript; available in PMC: 2020 Sep 4.
Published in final edited form as: Pain. 2019 Oct;160(10):2328–2337. doi: 10.1097/j.pain.0000000000001624

Table 1.

Cytosine-phosphate-guanine dinucleotide sites (and associated genes) showing differential methylation at an uncorrected P < 0.005 level between CRPS and non-CRPS chronic pain patients.

CpG site Gene Log FC t value P
cg17820060_chr1:103343469 COL11A1 −0.166219474 −5.623121047 9.98E-07
cg15591384_chr6:32525960 HLA-DRB6 −0.176122632 −3.955685059 0.000256198
cg00070715_chr5:138862796 TMEM173 −0.08300769 −3.939373128 0.000269618
cg01876338_chr2:54087008 GPR75 −0.065696053 −3.922495243 0.000284217
cg17854650_chr2:132481613 C2orf27A −0.062572719 −3.882752019 0.000321678
cg09518270_chr1:211308115 KCNH1 −0.237310731 −3.785369214 0.000434713
cg23803868_chr19:2340235 SPPL2B −0.412810322 −3.730180616 0.000514858
cg14832904_chr2:54087028 GPR75 −0.068758392 −3.671198847 0.000616167
cg20571420_chr22:25160308 TOP1P2; PIWIL3 −0.056746842 −3.54875351 0.000890954
cg10560079_chr2:191398806 TMEM194B 0.057021579 3.531565975 0.000937857
cg04375683_chr19:52692431 PPP2R1A −0.058455731 −3.506453217 0.001010652
cg10226967_chr19:16606648 C19orf44; CALR3 −0.055366199 −3.496832101 0.001039946
cg15975960_chr19:1035450 CNN2 −0.183742719 −3.482898424 0.001083811
cg04610742_chr1:230513809 PGBD5 −0.205357602 −3.434243521 0.001251244
cg25115829_chr17:29057586 SUZ12P −0.053363596 −3.380452852 0.00146496
cg13627197_chr22:25160378 TOP1P2; PIWIL3 −0.059896462 −3.354150242 0.001581692
cg23565757_chr7:157646605 PTPRN2 −0.080209854 −3.344032445 0.001628906
cg02675527_chr2:114030824 PAX8 0.119200439 3.341899694 0.001639028
cg03287111_chr2:121625634 GLI2 −0.051736842 −3.314028541 0.001776912
cg23206520_chr2:189158094 GULP1 −0.062407164 −3.30687498 0.001814038
cg26858423_chr1:6149477 KCNAB2 0.084953041 3.277223241 0.001975912
cg04573316_chr19:54216680 MIR519D −0.063664591 −3.230689232 0.002257805
cg22451923_chr6:32370879 BTNL2 −0.085751053 −3.230266241 0.002260534
cg23964386_chr9:114362249 PTGR1 −0.067227339 −3.229947345 0.002262593
cg01122627_chr11:1474386 BRSK2 −0.079350234 −3.210120217 0.002394169
cg03848831_chr11:2397685 CD81 −0.091655 −3.206372603 0.002419837
cg16929496_chr19:58952249 ZNF132 −0.054303684 −3.200189318 0.002462757
cg26805579_chr6:32372962 BTNL2 −0.083768012 −3.195461202 0.00249606
cg03870448_chr4:41214687 APBB2 −0.055146374 −3.183598257 0.0025815
cg02027878_chr7:150711138 ATG9B; NOS3 −0.049219181 −3.182685168 0.002588189
cg10330187_chr16:88666383 ZC3H18 −0.063355117 −3.169273341 0.002688349
cg24474852_chr1:230850050 AGT −0.07147886 −3.158041045 0.002775033
cg09701145_chr11:2019436 MIR675; H19 0.049746433 3.157926055 0.002775934
cg19846314_chr2:171680113 GAD1 0.052606901 3.153575381 0.002810223
cg18323236_chr1:24743029 NIPAL3 −0.066710292 −3.131413078 0.002991171
cg15975890_chr5:11903145 CTNND2 −0.05833652 −3.084777665 0.003408353
cg18584440_chr6:32370815 BTNL2 −0.084480673 −3.079664007 0.003457285
cg24212267_chr7:137801780 AKR1D1 −0.051366959 −3.054308822 0.003709806
cg15214448_chr17:13506230 HS3ST3A1 0.058285497 3.052583402 0.003727604
cg14989959_chr6:54711471 FAM83B 0.056408596 3.041369712 0.003845243
cg18683523_chr6:91297516 MAP3K7 −0.057792047 −3.01326307 0.00415557
cg22835630_chr15:25434030 SNORD115 −0.071314181 −3.007297156 0.004224389
cg07065756_chr7:2119340 MAD1L1 −0.045774766 −2.97828233 0.004574559
cg16320788_chr8:73794096 KCNB2 −0.05781769 −2.963333609 0.004765386
cg17275074_chr5:135701422 TRPC7 −0.058669094 −2.958925012 0.004823067
cg02844892_chr6:31370412 MICA −0.046332544 −2.957764382 0.004838361
cg13713922_chr2:121625577 GLI2 −0.050111784 −2.954838104 0.004877122
cg12580156_chr10:112588051 RBM20 −0.04473193 −2.948632141 0.004960286

Negative logFC and t values indicate lower methylation in the CRPS group.

CpG, cytosine-phosphate-guanine dinucleotide; CRPS, complex regional pain syndrome.