Table 2. Selective optimization of the carboetherification conditions ^a .

Entry	[Pd]/L	Base	Solvent	T (°C)	Yield b , c (ee) [%]
1	Pd2(dba)3/L3	NaOtBu	Toluene	80	40(87)
2	Pd2(dba)3/L3	NaOPh	Toluene	80	30(38)
3 d	Pd2(dba)3/L3	NaOtBu	DCM	80	45(33)
4	Pd2(dba)3/L3	NaOtBu	Toluene	20	55(95)
5	Pd A/L3	NaOtBu	Toluene	20	51(95)
6	Pd2(dba)3/L5	NaOtBu	Toluene	20	44(85)
7	Pd2(dba)3/L7	NaOtBu	Toluene	20	60(96)
8	Pd2(dba)3/L8	NaOtBu	Toluene	20	52(82)

^aUnless otherwise specified, all reactions were carried out with 5a (0.2 mmol), 2a (1 mmol, 5 eq.), a [Pd] source (0.005 mmol, 2.5 mol%), N-Me-Xiang-Phos (0.01 mmol, 5 mol%), base (0.4 mmol, 2 eq.), and H₂O (3.6 μL, 1 eq.) in a solvent (1 mL, 0.2 M).

^bYield of isolated product.

^cDetermined by chiral HPLC.

^dPd₂(dba)₃ was added to 5 mol%, and L3 was added to 10 mol%.