Table 1.
Baseline characteristics of participants included in analyses stratified by level of childhood adversity
| p-value | |||||
|---|---|---|---|---|---|
| n | 350 | 202 | |||
| Age (years) | (7.2) | (7.9) | ns | ||
| Age at oophorectomy (years) | (6.0) | (7.3) | ns | ||
| Time since oophorectomy (months) | (46.2) | (48.3) | ns | ||
| Time without hormones (months) | (41.3) | (43.0) | ns | ||
| History of cancer | (44.6) | (50.0) | ns | ||
| Previous hormone therapy use | (42.9) | (39.6) | ns | ||
| Current hormone therapy use | (28.0) | (25.7) | ns | ||
| Previous chemotherapy use | (26.9) | (32.2) | ns | ||
| ns | |||||
| Graduate school | (44.3) | (46.5) | |||
| College | (44.3) | (33.7) | |||
| Some College | (9.7) | (15.8) | |||
| High school | (0.9) | (4.0) | |||
| Some high school | (0.3) | (0.0) | |||
| 8th grade or less | (0.6) | (0.0) | |||
| ns | |||||
| White | (93.1) | (89.6) | |||
| African American | (0.6) | (2.0) | |||
| Asian | (0.9) | (0.0) | |||
| Hispanic | (2.3) | (3.0) | |||
| Other | (1.7) | (1.5) | |||
| Unknown or not disclosed | (2.9) | (4.0) | |||
| HADS total score | (6.7) | (7.1) | 0.0005 | ||
| HADS depression subscale score | (3.8) | (4.0) | 0.001 | ||
| HADS anxiety subscale score | (3.6) | (3.4) | 0.0009 | ||
| Attention deficit disorder | (1.1) | (2.0) | ns | ||
| Depression | (28.0) | (30.7) | 0.004 | ||
| Anxiety | (2.6) | (5.9) | ns | ||
| Neurological conditions | (3.7) | (3.5) | ns | ||
| Narcotics | (0.9) | (1.0) | ns | ||
| SERM antagonist/Aromatase inhibitor | (12.3) | (14.9) | ns | ||
| Tamoxifen/SERM | (9.1) | (7.9) | 0.03 | ||
| <0.0001 | |||||
| Abuse | |||||
| Emotional abuse | (1.7) | (58.9) | <0.0001 | ||
| Physical abuse | (1.1) | (38.6) | <0.0001 | ||
| Sexual abuse | (7.1) | (25.2) | <0.0001 | ||
| Neglect | |||||
| Emotional neglect | (3.1) | (50.5) | <0.0001 | ||
| Physical neglect | (0.3) | (12.4) | <0.0001 | ||
| Household dysfunction | |||||
| Parents divorced/separated | (10.6) | (53.0) | <0.0001 | ||
| Witnessed domestic violence | (0.6) | (12.9) | <0.0001 | ||
| Drug abuse in household | (2.9) | (46.0) | <0.0001 | ||
| Mental illness in household | (2.0) | (46.0) | <0.0001 | ||
| Incarceration of family member | (0.6) | (6.4) | 0.0001 | ||
ACE=Adverse Childhood Experiences; HADS=Hospital Anxiety and Depression Scale; SERM=Selective Estrogen Receptor Modulator; ns=Not Significant (p>0.05)
T-tests, Wilcoxon rank sum tests, and chi-square tests were used to assess whether sociodemographic information differed between ACE groups. Two-sided hypotheses were evaluated with significance defined as p<=0.05.