Table 4.
Nanoparticles in Phase III and postmarketing phases of clinical development.
| Phase III | |||
|---|---|---|---|
| Identifier | Study Title | Cancer | Status |
| NCT02123407 | Clinical Study on the Harvesting Lymph Nodes with Carbon Nanoparticles for Advanced Gastric Cancer | Gastric | Unknown |
| NCT00397761 | Capecitabine and Paclitaxel (Albumin-Stabilized Nanoparticle Formulation) in Treating Women Undergoing Surgery for Stage II or Stage III Breast Cancer | Breast | Unknown |
| NCT04033354 | A Randomized, Double-blind, Placebo Controlled Phase III Study to Investigate Efficacy and Safety of First-Line Treatment With HLX10 + Chemotherapy (Carboplatin-Nanoparticle Albumin Bound (Nab) Paclitaxel) in Patients With Stage IIIB/IIIC or IV NSCLC | Lung | Recruiting |
| NCT01583426 | Nanoparticle-based Paclitaxel vs Solvent-based Paclitaxel as Part of Neoadjuvant Chemotherapy for Early Breast Cancer (GeparSepto) | Breast | Unknown |
| NCT00785291 | Paclitaxel, Nab-paclitaxel, or Ixabepilone With or Without Bevacizumab in Treating Patients With Stage IIIC or Stage IV Breast Cancer | Breast | Active, not recruiting |
| NCT00989131 | Study of Paclitaxel in Patients With Ovarian Cancer | Ovarian | Completed |
| NCT00046527 | Study of ABI-007 and Taxol in Patients With Metastatic Breast Cancer | Breast | Completed |
| NCT01644890 | A Phase III Study of NK105 in Patients With Breast Cancer | Breast | Completed |
| NCT04137653 | Treatment of Triple-negative Breast Cancer With Albumin-bound Paclitaxel as Neoadjuvant Therapy: a Prospective RCT | Breast | Not yet recruiting |
| NCT03875092 | A Study of Carboplatin-Paclitaxel/Nab-Paclitaxel Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With First Line Metastatic Squamous Non-small Cell Lung Cancer (MK-3475–407/KEYNOTE-407)-China Extension Study | Lung | Active, not recruiting |
| NCT02775435 | A Study of Carboplatin-Paclitaxel/Nab-Paclitaxel Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With First Line Metastatic Squamous Non-small Cell Lung Cancer (MK-3475–407/KEYNOTE-407) | Lung | Active, not recruiting |
| NCT04060472 | Paclitaxel (Albumin-bound) and Oxaliplatin for Advanced Hepatobiliary and Malignant Tumors | Hepatobiliary | Not yet recruiting |
| NCT04261777 | Ferumoxtran-10-enhanced MRI in Prostate Cancer Patients | Prostate | Recruiting |
| NCT03768414 | Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract Cancers | Biliary | Recruiting |
| NCT02379845 | NBTXR3 Crystalline Nanoparticles and Radiation Therapy in Treating and Randomized Patients in Two Arms With Soft Tissue Sarcoma of the Extremity and Trunk Wall | Soft Tissue | Active, not recruiting |
| NCT04233866 | Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread | Pancreatic | Not yet recruiting |
| Postmarketing Phase | |||
| Identifier | Study Title | Cancer | Status |
| NCT03799679 | Albumin-Bound Paclitaxel Followed by Epirubicin in Combination With Cyclophosphamide in Triple Negative Breast Cancer | Breast | Recruiting |
| NCT03799692 | Albumin-Bound Paclitaxel Combined With Carboplatin as Neoadjuvant Chemotherapy in Luminal B/HER-2 Negative Breast Cancer | Breast | Recruiting |
| NCT00920023 | Pre-Operative Staging of Pancreatic Cancer Using Superparamagnetic Iron Oxide Magnetic Resonance Imaging (SPIO MRI) | Pancreatic | Completed |
| NCT03401827 | The Effect of Gemcitabine Plus Nab-paclitaxel as Secondary Chemotherapy in Advanced Pancreatic Cancer | Pancreatic | Unknown |