Table 4.

Multivariable adjusted associations between adiposity at age 10 and mammographic density measures stratified by age at menarche^a.

	N	Volumetric Percent Density (%)			Dense Volume (cm3)			Non-dense Volume (cm3)
		Diff%b	95% CL	P-valuec	Diff%	95% CL	P-valuec	Diff%	95% CL	P-valuec
Age at menarche <12.81 years
BMI at age 10		−6.37	−9.17, −3.50	<0.001	−1.63	−4.03, 0.83	0.190	6.26	2.61, 10.04	<0.001
Age at menarche ≥12.81 years
BMI at age 10		−6.37	−8.99, −3.67	<0.001	−0.32	−2.40, 1.81	0.765	7.19	3.57, 10.95	<0.001
Age at menarche <12.81 years
Body size at age 10
1–2	65	Ref			Ref			Ref
3–4	66	−24.36	−38.06, −7.63	0.007	−12.83	−25.88, 2.52	0.096	24.13	−1.44, 56.33	0.066
5	27	−35.65	−50.32, −16.67	0.001	−6.90	−24.53, 14.85	0.502	56.96	16.45, 111.57	0.003
6+	12	−44.19	−60.69, −20.77	0.001	−17.93	−38.25, 9.09	0.172	63.03	8.78, 144.33	0.018
Age at menarche ≥12.81 years
Body size at age 10
1–2	93	Ref			Ref			Ref
3–4	63	−5.64	−21.91, 14.01	0.546	12.12	−2.44, 28.86	0.106	19.46	−5.02, 50.24	0.128
5	24	−30.61	−47.11, −8.97	0.009	6.04	−13.15, 29.48	0.563	60.26	15.33, 122.70	0.005
6+	15	−48.55	−62.85, −28.75	<.001	−9.63	−28.87, 14.82	0.405	87.56	26.42, 178.28	0.002

^aAll models are adjusted for attained age, birth index, family history of breast cancer, and race.

^bPercentage differences (%Diff) represents one unit change in an adiposity measure associated with one unit change in Volumetric Percent Density, Dense Volume, or Non-dense Volume

^cMultivariable linear regression models were used to evaluate the associations of adiposity at age 10 with mammographic density measures. The p-values for body size compare each category to the reference category. The p-values for BMI test for trends