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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Adv Mater. 2020 May 8;32(25):e2000660. doi: 10.1002/adma.202000660

Figure 3.

Figure 3.

Preparation of PCM nanoparticles through anti-solvent-induced precipitation in a fluidic device. (A) Schematic illustration of the fluidic device used for producing PCM nanoparticles. As the ethanol solution of PCM and an aqueous solution meet and mix along the flow, the PCM precipitates out as nanoparticles at the interface between the focusing and focused phases. Phospholipids are typically used to stabilize the nanoparticles. Therapeutic agents and photothermal dyes can be easily loaded into the PCM nanoparticles by dissolving them in the PCM solution. (B) TEM image of the as-prepared PCM nanoparticles. (C) Size distribution of the PCM nanoparticles prepared at different flow rate ratios (FRRs) between the focusing and focused phases. Reproduced with permission.[46] Copyright 2017, Royal Society of Chemistry.