Table 2. Proportions of the 10 most commonly mutated genes in Hispanic Latino women with metastatic triple-negative breast cancer at TTUHSC El Paso compared with other databases.
| TTUHSC | TCGA | COSMIC | METABRIC | (Chinese study) | (Thai study) | |
|---|---|---|---|---|---|---|
| Mutated | (n = 25) | (n = 93) | (n = 407) | (n = 159) | (n = 465) | (n = 116) |
| Gene | % (P-value) | % (P-value) | % (P-value) | % (P-value) | % (P-value) | % (P-value) |
| TP53 | 100 | 82.8 (0.025) | 51 (<0.0001) | 81.8 (0.02) | 74 (0.003) | 75.9 (0.006) |
| NOTCH | 44 | --- | 2 (<0.0001) | 6.3 (<0.0001) | --- | --- |
| AKT | 28 | --- | 1 (<0.0001) | 2.5 (<0.0001) | --- | --- |
| MAP3K1 | 28 | --- | n/r | 2.5 (<0.0001) | --- | --- |
| PIK3CA | 20 | 8.6 (0.106) | 10 (0.114) | 13.8 (0.415) | 18 (0.8) | 23.3 (0.721) |
| EGFR | 20 | --- | 2 (<0.0001) | 1.9 (<0.0001) | --- | --- |
| PTEN | 16 | 1.08 (0.001) | 4 (0.006) | 6.3 (0.089) | 6 (0.048) | 11.2 (0.504) |