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. Author manuscript; available in PMC: 2020 Sep 4.
Published in final edited form as: Cell Rep. 2020 Apr 14;31(2):107495. doi: 10.1016/j.celrep.2020.03.059

Figure 1. Tbr1 Regulates Genes that Are Implicated in Controlling the Development of Axons, Synapses, and Dendrites in Layer 5 Pyramidal Neurons of the mPFC.

Figure 1.

(A) t-distributed stochastic neighbor embedding (t-SNE) plot displaying 11,070 single neuronal cells from Tbr1layer5 WT (red) and from Tbr1layer5 heterozygous (HET; green), and Tbr1layer5 homozygous (NULL; blue) CKOs. t-SNE was performed after quality control and removal of non-neuronal cell subtypes.

(B) Heatmap of DEX genes (FDR < 0.05) shared between both genotypes (x axis, n = 218) over a randomly selected 1,000 cells from each genotype (y axis, n = 3,000). Genes are ordered by hierarchal clustering within direction of regulation grouping, and the Z score of normalized gene expression data is shown. The genotype for each cell is depicted at the top, and genes with membership in selected enriched GO categories are highlighted at the right.

See also Figures S1-S3.