Table 3.

Characteristics of patients with cardiac dysfunction

Patient	Prior anthracycline exposure (mg/m2)	Baseline LVEF, %	Lowest LVEF, %	Max CRS* grade	Vasoactive support?	Troponin elevation?	Peak troponin (ng/mL)
14	360	64	20	4	Yes	Yes	6.23
16	110	70	45	4	No	Yes	0.117
39	195	60	25	3	No	Yes	0.113
45	570	55	10	4	Yes	No†	<0.010
51	355	50	40	2	No	No†	<0.010
52	180	61	45	2	Yes	Yes	0.016

Cardiac dysfunction is defined as a >10% absolute decrease in left ventricular ejection fraction (LVEF) compared with baseline or new onset left ventricular systolic dysfunction >grade 2, LVEF <50%.

*CRS max grade as per Lee et al, Blood 2014.

†Troponin levels were drawn and undetectable, lower limit of detection 0.010 ng/mL.

CRS, cytokine release syndrome.