Figure 4. Time-dependent changes in pathways and cerebral cortical derived proteins that mapped to the pathways after a single mild TBI.

Changes in protein numbers that mapped to Pathological – Cell Death (A), Physiological – Cell Survival (B/C) and Context-Dependent Pathways (D) are provided. Pathological pathways were observed from 8 hr up to, but not after 14 days following injury, the apoptosis pathway showed the largest number of proteins at 72 hr after injury (A). Physiological pathways were shown to be observed at times similar to that of Pathological pathways, yet in contrast to those, cell survival pathways were present at the 30 day time point. The numbers of proteins that mapped to the cell survival pathways were similar during the study (B/C). Context-dependent pathways were also observed at all times during the study, the pathways which had the largest number of proteins was the inflammation pathway (eight proteins by 24 hr and six proteins at 7 days following TBI (D). The pathways were derived from the identities of the proteins significantly regulated at each time point which were analyzed by the Protein ANalysis THrough Evolutionary Relationships (PANTHER) bioinformatic tool. Figure 4—source data 1.