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Mouse breeding scheme. (A) Cross between XX females and XPafY males generates XMO females carrying maternal X chromosomes and XXPaf females. Cross between XXPaf females and XY males produces XPafY males. By using B6 XX and XY mice for crosses, the genetic background gets closer to B6 at every generation (backcross). (B) Cross between XMO females and XY males generates XPO females carrying paternal X chromosomes. YO embryos die before implantation.
