Table 3.
Correlation parameters between S100A8/S100A9 and the 49 protein intensities correlated to the histological inflammatory score.
| S100A8 | S100A9 | |||
|---|---|---|---|---|
| Pearson r | P value | Pearson r | P value | |
| Protein S100A8/A9 | 0.9545 | *** | 0.9545 | *** |
| Neutrophil defensin | 0.9131 | *** | 0.8637 | *** |
| Lymphocyte-specific protein 1 | 0.8527 | *** | 0.8197 | *** |
| Coronin-1A | 0.8417 | *** | 0.8041 | *** |
| Plastin-2 | 0.837 | *** | 0.8021 | *** |
| Cathepsin Z | 0.8266 | *** | 0.7937 | *** |
| Myeloid cell nuclear differentiation antigen | 0.8118 | *** | 0.7771 | *** |
| Tapasin | 0.7384 | *** | 0.6698 | ** |
| Profilin-1 | 0.7348 | *** | 0.6748 | *** |
| Mesencephalic astrocyte-derived neurotrophic factor | 0.7223 | *** | 0.7417 | *** |
| Cathepsin S | 0.7125 | *** | 0.6177 | ** |
| Receptor-type tyrosine-protein phosphatase C | 0.707 | *** | 0.643 | *** |
| Rho GDP-dissociation inhibitor 2 | 0.6958 | *** | 0.6217 | ** |
| Calreticulin | 0.68 | *** | 0.6088 | ** |
| Cytosol aminopeptidase | 0.679 | *** | 0.6264 | ** |
| Marginal zone B- and B1-cell-specific protein | 0.667 | ** | 0.7098 | ** |
| Elongation factor 1-gamma | 0.6522 | *** | 0.5827 | ** |
| Lamin-B1 | 0.6505 | *** | 0.587 | ** |
| Echinoderm microtubule-associated protein-like 4 | 0.6346 | ** | 0.5933 | ** |
| Phosphomannomutase 2 | 0.614 | ** | 0.6091 | ** |
| Endoplasmic reticulum resident protein 29 | 0.5962 | ** | 0.644 | *** |
| Peroxiredoxin-4 | 0.578 | ** | 0.5787 | ** |
| Protein canopy homolog 2 | 0.5758 | ** | 0.6744 | *** |
| Signal transducer and activator of transcription 1-alpha/beta | 0.5704 | ** | 0.5427 | ** |
| DnaJ homolog subfamily B member 11 | 0.5504 | ** | 0.5635 | ** |
| Interferon-induced guanylate-binding protein 1 | 0.5373 | ** | 0.566 | ** |
| Hypoxia up-regulated protein 1 (GRP170) | 0.5357 | ** | 0.5298 | ** |
| 78 kDa glucose-regulated protein (GRP78) or BiP | 0.5233 | ** | 0.5043 | * |
| Endoplasmin | 0.5164 | ** | 0.4804 | * |
| Isocitrate dehydrogenase [NADP], mitochondrial | 0.5118 | * | 0.4164 | * |
| Protein disulfide-isomerase A4 | 0.5076 | * | 0.4499 | * |
| Protein ERGIC-53 | 0.4971 | * | 0.4479 | * |
| Tubulin alpha-4A chain | 0.4941 | * | 0.4951 | * |
| Neutral alpha-glucosidase AB | 0.483 | * | 0.396 | ns |
| Guanine nucleotide-binding protein subunit beta-2-like | 0.4502 | * | 0.3353 | ns |
| Signal recognition particle subunit SRP72 | 0.4444 | * | 0.4308 | * |
| Thioredoxin domain-containing protein 5 | 0.4049 | * | 0.4182 | * |
| Poly [ADP-ribose] polymerase 1 | 0.3561 | ns | 0.2772 | ns |
| Cartilage acidic protein 1 | − 0.3355 | ns | − 0.3434 | ns |
| Heat shock 70 kDa protein 1A/1B (HSP70-1) | − 0.5366 | ** | − 0.5838 | ** |
| LEM domain-containing protein 2 | − 0.6254 | ** | − 0.5722 | ** |
| Nesprin-3 | − 0.6296 | ** | − 0.6015 | ** |
| Tenascin-X | − 0.6321 | ** | − 0.5679 | ** |
| Spectrin beta chain, non-eryththrocytic 1 | − 0.6884 | *** | − 0.6734 | *** |
| Scavenger receptor class A member 5 | − 0.7069 | ** | − 0.6619 | ** |
| Carboxypeptidase Q | − 0.7156 | *** | − 0.7019 | ** |
| Lamin-B2 | − 0.7414 | *** | − 0.7293 | *** |
| Glutathione peroxidase 3 | − 0.7475 | *** | − 0.7667 | *** |
| Beta-2-syntrophin | − 0.7522 | *** | − 0.8171 | *** |
| Creatine kinase B-type | − 0.7555 | *** | − 0.7136 | *** |
Alarmins S100A8 and S100A9 were both correlated to the 50 other protein intensities obtained by MS/MS and correlated to the histological inflammatory score. r = coefficient correlation (Pearson test). *, **, *** Represent P-values < 0.05; 0.01 and 0.001, respectively.
ns not significant.